These common heterocyclic compound, 501-00-8, name is 2-(3-Fluorophenyl)acetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C8H6FN
3-Fluorophenylacetonitrile (135 mg, 1 mmol),Benzyl alcohol (119 mg, 1.1 mmol), [Rh (cod) Cl] 2 (4.9 mg, 0.01 mmol, 1 mol%),Triphenylphosphine (26 mg, 0.1 mmol, 10 mol%),Potassium hydroxide (22 mg, 0.4 mmol, 40 mol%) were added successively to 10 ml of a microwave reaction tube.The mixture was reacted at 130 C for 2 hours and then cooled to room temperature. The solvent was removed by rotary evaporation and then the title compound was obtained by column chromatography (developing solvent: ethyl acetate / petroleum ether) in 89% yield.
The synthetic route of 2-(3-Fluorophenyl)acetonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nanjing University of Science and Technology; Li, Feng; Lu, Lei; Wang, Nana; (15 pag.)CN105985256; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts