Reference of 69395-13-7, A common heterocyclic compound, 69395-13-7, name is 4-(2-Hydroxyethyl)benzonitrile, molecular formula is C9H9NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The following examples were prepared in a similar manner to that described in Scheme 38.; The mesylate prepared in step 1 (63 mg), piperazine Example 304 (80 mg), K2CO3 (97 mg), and NaI (40 mg) were taken up in CH3CN and heated at reflux (90 C., 18 h). The solution was partitioned between EtOAc and water. The aqueous layer was extracted with EtOAc. The combined organic layers were washed with brine and dried (MgSO4). Filtration and concentration gave a yellow oil. Purification via thin-layer preparative chromatography (7% EtOAc in CH2Cl2, SiO2) gave 100 mg (90%) of Example 323 as a colorless oil.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Gilbert, Eric J.; Greenlee, William J.; Miller, Michael W.; Scott, Jack D.; Stamford, Andrew W.; US2013/72468; (2013); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts