Synthetic Route of 868-54-2,Some common heterocyclic compound, 868-54-2, name is 2-Aminoprop-1-ene-1,1,3-tricarbonitrile, molecular formula is C6H4N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: In a 20 mL reaction vial, 4-hydroxycarbazole 1{1} (0.183g, 1mmol) with benzaldehyde 2{1} (0.106g, 1mmol), and 2-aminoprop-1-ene-1,1,3-tricarbonitrile 3 (0.132g, 1mmol) and ethanol (3 mL), as well as EtONa (0.064g, 1mmol)were mixed and then capped (the automatic mode stirring helped the mixing and uniform heating of the reactants). The mixture was heated for 15 min at 80 C under microwave irradiation. Upon completion, confirmed by TLC, the reaction mixture was cooled to room temperature. The crystalline solid product was collected by Buchner filtration, subsequently washed with two different solvents of ethanol and ethylether in sequence to give the pure product 4{1,1}.
The synthetic route of 868-54-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Zhang, Wenhui; Wang, Jianqiang; Mao, Jingpeng; Hu, Li; Wu, Xiaohua; Guo, Cheng; Tetrahedron Letters; vol. 57; 18; (2016); p. 1985 – 1989;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts