Brief introduction of 2-(3,5-Dimethoxyphenyl)acetonitrile

According to the analysis of related databases, 13388-75-5, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13388-75-5, name is 2-(3,5-Dimethoxyphenyl)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C10H11NO2

To a stirred solution of 5 (2.0 g, 11.28 mmol) in dry CH2CI2 (125 mL), at -78C, under an argon atmosphere, was added boron tribromide (3.75 mL, 39.48 mmol). Following the addition, the reaction mixture was gradually warmed to room temperature and the stirring was continued at that temperature until completion of the reaction (2 days). The reaction mixture was then poured into a mixture of aqueous saturated NaHC03/crushed ice. The mixture was warmed to room temperature and volatiles were removed in vacuo. The residue was diluted with ethyl acetate and washed with saturated NaHCOs solution, water and brine. The organic layer was dried (MgSC^), filtered and concentrated under reduced pressure. Purification by flash column chromatography on silica gel (40% ethyl acetate in hexanes) afforded 1.42 g (85% yield) of 10 as a white solid, mp 144-146C. 1H NMR (500 MHz, CDCl3/DMSO-d6) delta 8.69 (s, 2H, OH), 6.34 (m, 1H, 2-H), 6.33 (m, 2H, 4-H, 6-H), 3.59 (s, 2H, -CH2CN).

According to the analysis of related databases, 13388-75-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NORTHEASTERN UNIVERSITY; MAKRIYANNIS, Alexandros; D’SOUZA, Marsha, R.; BAJAJ, Shama; NIKAS, Spyridon, P.; THAKUR, Ganeshsingh, A.; WO2014/62965; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts