Electric Literature of 630-18-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 630-18-2, name is Pivalonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Reference Example 20 (1Z)-N’-hydroxy-2,2-dimethylpropanimidamide; A mixture of trimethylacetonitrile (41.9 g, 504 mmol), 50% hydroxylamine solution (100 mL, 1512 mmol), and ethanol (200 mL) was heated under reflux for 16 hr. The reaction mixture was concentrated, toluene was added thereto, and the remaining water was removed by azeotropic distillation under reduced pressure. To the residue was added ethyl acetate, and the mixture was dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated. The residue was crystallized from ethyl acetate to give the title compound as colorless crystals (58.5 g, yield quaint.). 1H-NMR (300 MHz, CDCl3)delta:1.19 (s, 9 H), 4.60 (br. s., 2 H), 8.22 (br. s., 1 H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Pivalonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Takeda Pharmaceutical Company Limited; EP2399914; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts