Some common heterocyclic compound, 42872-73-1, name is 2-Bromo-4-methylbenzonitrile, molecular formula is C8H6BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 42872-73-1
To a solution of compound 1 (19.6 g, 100 mmol) in H2SO4 (80 mL) was added HNO3 (80 mL) at 0 C. The mixture was heated to 60 C. for 1 h, cooled to rt and poured into ice water and extracted with EtOAc. The combined extracts were dried over Na2SO4, filtered and concentrated. The residue was purified by silica gel chromatography (petroleum ether/EtOAc=3/1) to give the desired product (17.3 g, 71.7 mmol, 71.7%) as a yellow solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 42872-73-1, its application will become more common.
Reference:
Patent; CoMentis, Inc.; BILCER, Geoffrey M.; NG, Raymond; (104 pag.)US2016/9706; (2016); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts