Adding a certain compound to certain chemical reactions, such as: 2469-99-0, name is 3-Oxobutanenitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2469-99-0, Application In Synthesis of 3-Oxobutanenitrile
39 mg (0.3 mmol) of acetyl acetonitrile is added to 89 mg (0.3 mmol) of the third compound.Mix 5 mL of absolute ethanol for 3-5 minutes.Then add piperidine 5 muL,The temperature was raised to 78 C to carry out the reaction.TLC monitors the reaction until the third compound is completely reacted,The reaction is over,And add 20-30ml 10M HCl solution, heated for 30min,Adjust the pH to neutral with saturated sodium bicarbonate,Then extract with dichloromethane,Washed 4 times with saturated brine,Collect organic phase,And dried with anhydrous Na2SO4,Filter to obtain the filtrate,The solvent was distilled off under reduced pressure.Purification by column chromatography (V petroleum ether: V dichloromethane = 2:1) gave 79 mg of red powder, which is a phenothiazine coumarin dye 5B with a large Stokes shift, Mp of 141-143 C, yield 72%,
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Oxobutanenitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Guangxi Normal College; Sheng Jiarong; Chen Wenqiang; Yue Xiuxiu; Huang Chusheng; (29 pag.)CN108250220; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts