Some common heterocyclic compound, 868-54-2, name is 2-Aminoprop-1-ene-1,1,3-tricarbonitrile, molecular formula is C6H4N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C6H4N4
General procedure: A solution of 0.264 g (2 mmol) of2-aminoprop-1-ene-1,1,3-tricarbonitrile and 0.088 g(2 mmol) of freshly distilled acetaldehyde in 5 mL of1,4-dioxane containing a catalytic amount of piperidiniumacetate was stirred for 2 h at 60C. A solution of0.320 g (2 mmol) of bromine in a mixture of 1 mL ofconcentrated aqueous HBr and 2 mL of 1,4-dioxanewas then added, and the mixture was stirred for 4 hat 70C. When the reaction was complete (TLC), themixture was cooled, neutralized to pH 7 witha 5% aqueous solution of sodium carbonate, anddiluted with 20 mL of water. A tarry material separatedand was ground in water until a solid precipitate wasobtained. It was filtered off, washed with a smallamount of isopropyl alcohol and distilled water, and recrystallized from ethyl acetate.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 868-54-2, its application will become more common.
Reference:
Article; Bardasov; Alekseeva, A. Yu.; Ershov; Russian Journal of Organic Chemistry; vol. 54; 7; (2018); p. 1106 – 1108; Zh. Org. Khim.; vol. 54; 7; (2018); p. 1098 – 1099,2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts