Electric Literature of 876-31-3, These common heterocyclic compound, 876-31-3, name is 4-(Cyanomethyl)benzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Under N2 atmosphere, dinitrile 1 (0.2 mmol), potassium phenyltrifluoroborate 2 (147 mg, 0.8 mmol), Pd(OAc)2 (4.49 mg, 10 mol %), L4 (7.2 mg, 20 mol %), TFA/H2O (0.4 mL/0.4mL), and 2-MeTHF (2 mL) were successively added into a Schlenk reaction tube. The reaction mixture was stirred vigorously at 80 C for 48 h. After the completion of the reaction, the mixture was poured into ethyl acetate, which was washed with saturated NaHCO3 (2 × 10 mL) and then brine (1 × 10 mL). After the aqueous layer was extracted with ethyl acetate, the combined organic layers were dried over anhydrous Na2SO4 and evaporated under reduced pressure. The residue was purified by flash column chromatography (hexane/ethyl acetate) to afford the desired products 3. The physical and spectroscopic data of compounds 3a-h follow.
Statistics shows that 4-(Cyanomethyl)benzonitrile is playing an increasingly important role. we look forward to future research findings about 876-31-3.
Reference:
Article; Wang, Xingyong; Wang, Qingzong; Chen, Jiuxi; Liu, Miaochang; Ding, Jinchang; Wu, Huayue; Journal of Chemical Research; vol. 37; 8; (2013); p. 470 – 472;,
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