Electric Literature of 6136-68-1, A common heterocyclic compound, 6136-68-1, name is 3-Acetylbenzonitrile, molecular formula is C9H7NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a 1:1 chloroform and methanol solution (16ml) of aldehyde 1 (10.2 mg, 18.5 mumol) and p-nitroacetophenone (0.98 g, 5.9 mmol), was added 28% sodium methoxide in methanol (1 ml, 5 mmol). After being stirred in an ice bath for 30 min, the reaction mixture was washed with an aqueous 2% hydrochloric acid solution, an aqueous saturated sodium hydrogen carbonate solution and distilled water, and dried over sodium sulfate. The solvents were evaporated and the residue was purified with FCC (5-6% Et2O-CH2Cl2) and recrystallization (CH2Cl2-hexane) to give 2i (4.3 mg, 6.2 mumol, 33% isolated yield).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Ohashi, Kota; Kinoshita, Yusuke; Tamiaki, Hitoshi; Tetrahedron; vol. 74; 22; (2018); p. 2703 – 2715;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts