Application of 3556-60-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3556-60-3, name is 3-Methoxy-4-methylbenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Under an inert atmosphere, to a solution of 3-methoxy-4-methylbenzonitrile (2.00 g, 13.6 mmol) in tetrahydrofuran (50 mL), a methylmagnesium chloride solution (5 mL, 3M in tetrahydrofuran) was added dropwise during cooling with ice at 0-2 C, and the mixture was stirred at 40 C for 12 hours. (0195) The reaction mixture was quenched by dropwise addition of 6 M HC1 solution (3.4 mL), and was stirred stirred at 40 C for another hour. The mixture was extracted with ethyl acetate, the combined organic layer was washed with brine, dried over Na?.S04, evaporated, and the crude residue was purified with column chromatography on silica gel with gradient elution, using a mixture of dichlorom ethane and cyclohexane as eluent. Yield: 356 mg (16 %).
The synthetic route of 3-Methoxy-4-methylbenzonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; RICHTER GEDEON NYRT.; LEDNECZKI, Istvan; ELES, Janos; TAPOLCSANYI, Pal; JABLONKAI, Erszebet; GABOR, Eszter; VISEGRADI, Andras; NEMETHY, Zsolt; LEVAY, Gyoergy Istvan; PETRO, Jozsef Levente; SELENYI, Gyoergy; (0 pag.)WO2020/12423; (2020); A1;,
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