Electric Literature of 71825-51-9,Some common heterocyclic compound, 71825-51-9, name is 2-Methyl-2-(4-nitrophenyl)propanenitrile, molecular formula is C10H10N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 107a; (2- (4-Amino-phenyl)-2-methyl-propionitrile; 3.8 g (20 mmol) of 2-methyl-2- (4-nitro-phenyi)-propionitrile (Example 10b) and 1 g of Raney-Ni are shacked in 50 mL of THF-MeOH (1: 1) under 1.1 bar of H2 for 4 h at RT. After completion of the reaction, the catalyst is filtered-off and the filtrate is evaporated to dryness. The residue is purified by flash chromatography on silica gel (hexane-EtOAc 3: 1 to 1: 2) to give the title compound as an oil : ES-MS: 161 (M+H) + ; analytical HPLC: tret= 2.13 minutes (Grad 2).
The synthetic route of 71825-51-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2005/54238; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts