Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 50712-68-0, name is 4-Chloro-2-methylbenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 50712-68-0
In a 500 mE round-bottom flask, 4-chloro-2-meth- ylbenzonitrile (10 g, 66 mmol) was dissolved in 200 mE of methanol. To the mixture was added hydroxylammonium chloride (4.56 g, 66 mmol) followed by DIEA (diisopropylethylamine) (23 mE, 132 mmol). The mixture was heated at reflux for overnight. The solvents were removed. The residue was dissolved in 200 mE of CHC13. To the mixture was added 2-throyl chloride (10.5 ml, 66 mmol) followed by DIEA (23 mE, 132 mmol). Afier reaction completion, the mixture was extracted with chloroform and watet The organic layer was separated, washed with brine, dried over Na2SO4, filtered and evaporated to dryness. The residue was dissolved in 200 mE of dioxanes. To the mixture was added 1 eq of DId (N, N?-diisopropylcarbodiimide) followed by 1 eq of DIEA. The mixture was then heated at reflux overnight. Afier reaction completion, the mixture was cooled down. The solvents were removed in vacuo. The residue was then extracted with ethyl acetate and watet The organic layer was separated, washed with brine, dried over Na2SO4, filtered and evaporated to dryness. The crude was purified by flash chromatography on silica gel in a 0-20% ethyl acetate hexanes gradient to afford 4.96 g of the desired compound 3-(4-Chloro-2-methyl-phenyl)-5-thran-2-yl-[1 ,2,4-]oxadi- azole as a white powder in an overall yield of 28.8%.
According to the analysis of related databases, 50712-68-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Monsanto Technology LLC; Shortt, Barry J.; South, Michael S.; Wideman, Al S.; Williams, Deryck Jeremy; (34 pag.)US2018/228158; (2018); A1;,
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