Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4553-07-5, name is Ethyl 2-cyano-2-phenylacetate, A new synthetic method of this compound is introduced below., HPLC of Formula: C11H11NO2
General procedure: To a solution of methyleneindolinone (0.1 mmol, 1equiv) and isocyanide 1a (0.15 mmol, 1.5 equiv) in DCM (0.2 mL) was added catalyst VI (0.01 mmol, 0.1 equiv). The resulting mixture was stirred at room temperature (23 C). After thereaction completed, the mixture was quenched with water (5 mL) and extracted with DCM (2 x 5mL). The combined organic layer was washed with brine and dried over Na2SO4. The solvent was then removed under reduced pressure. The product was afforded by silica gel flash chromatography using gradient elution (EtOAc/Hexane = 1:10 to 1:6).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Tan, Bin; Zhang, Xuan; Zhong, Guofu; ARKIVOC; vol. 2014; 3; (2014); p. 124 – 142;,
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