Extracurricular laboratory: Synthetic route of C6H9NO

According to the analysis of related databases, 29509-06-6, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 29509-06-6, name is 4-Methyl-3-oxopentanenitrile, This compound has unique chemical properties. The synthetic route is as follows., Formula: C6H9NO

General procedure: A mixture of 4-methyl-3-oxopentanenitrile 10i or 10ii (1.5eq), aldehyde 6(a-m) (1.0 eq), urea (1.5 eq) and CuCl (0.01eq) in MeOH containing concentrated H2SO4 (0.62 eq) wasstirred at reflux temperature for 3-5 days. After the reactionwas deemed complete by TLC, methanol was removed byconcentration in vacuo. The precipitated solid was extractedin dichloromethane. The dichloromethane layer was washedwithwater twice so as to removewater soluble impurities. Theorganic layerwas concentrated again to dryness in vacuo. Thecrude residue was purified by silica gel column chromatographyusing ethyl acetate: hexanes to give pyrimidine compound11(a-m).

According to the analysis of related databases, 29509-06-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Pachore, Sharad S; Ambhaikar, Narendra B; Siddaiah, Vidavalur; Khobare, Sandip R; Kumar, Sarvesh; Dahanukar, Vilas H; Kumar, U K Syam; Journal of Chemical Sciences; vol. 130; 6; (2018);,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts