34403-48-0, name is 4-((Methylamino)methyl)benzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C9H10N2
To a solution of compound 222 (1 mmol), Aldehyde/ketone (1 mmol), in THF was added NaBH3CN (2 mmol). The reaction mixture was stirred at room temperature overnight. After disappearance of the starting material as indicated by TLC, a solution of saturated NH4C1 solution (5 mL) was added dropwise at room temperature. The mixture was then diluted with Et20 (30 mL) and washed three times with water (30 mL), and brine (30 mL). Organic layer was dried over Na2S04, concentrated under vacuum, and the residue was purified by column chromatography to provide compound 223.
The synthetic route of 34403-48-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NORTHWESTERN UNIVERSITY; SILVERMAN, Richard, B.; WANG, Hua; KHANFAR, Mohammad; WO2014/100833; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts