Some common heterocyclic compound, 185836-35-5, name is 4-(Benzyloxy)-2-fluorobenzonitrile, molecular formula is C14H10FNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 4-(Benzyloxy)-2-fluorobenzonitrile
To the resulting Grignard reagent was dropwise added a solution of 2-fluoro-4-benzyloxybenzonitrile (0.35 mol) in dry ether (1 l) below 20 C., and the mixture was heated for 10 hours under reflux, and then acidified with dilute sulfuric acid. Ether layer was separated, washed with water and the ether evaporated to dryness to obtain 2-fluoro-4-benzyloxy phenyl 5-methyl-heptyl ketone 896.3 g) as residue.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 185836-35-5, its application will become more common.
Reference:
Patent; Chisso Corporation; US4780242; (1988); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts