Application of 1009-35-4, The chemical industry reduces the impact on the environment during synthesis 1009-35-4, name is 4-Fluoro-3-nitrobenzonitrile, I believe this compound will play a more active role in future production and life.
[019Theta] A solution of 4-(2-fluoro-4-methoxyphenoxy)piperidine hydrochloride (0.785 g, 3 mmol), 4-fluoro-3-nitrobenzonitrile (0.598 g, 3.60 mmol) and K2CO3 (1.244 g, 9.00 mmol) in DMSO (9.09 mL) was stirred at 80°C overnight. Tire reaction mixture was subsequently partitioned between EtOAc and water, and the organic layer was washed with water (2 x) and dried over anhydrous Na?,SQ4. The solvent was evaporated to give the title compound as a yellow solid, which was used without further purification (1.005 g, 90percent). ESI-MS m/z [M+H] 372.3.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Fluoro-3-nitrobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; GREEN, Jason; HOPKINS, Maria; JONES, Benjamin; KIRYANOV, Andre A.; KUEHLER, Jon; MONENSCHEIN, Holger; MURPHY, Sean; NIXEY, Thomas; SUN, Huikai; (300 pag.)WO2018/183145; (2018); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts