Related Products of 34403-48-0, A common heterocyclic compound, 34403-48-0, name is 4-((Methylamino)methyl)benzonitrile, molecular formula is C9H10N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A round-bottom flask was charged with norbornane-2-carboxylic acid (1.0 g, 1 eq.) and thionyl chloride (O.95 g, 2 eq.) was added dropwise. The mixture was warmed to 70 C. for 1 hour. The mixture was cooled to room temperature and dichloromethane (20 mL) was added. Subsequently 4-(methylaminomethyl)benzonitrile (1.03 g, 1.1 eq) was added portion wise. The mixture was stirred at room temperature over night until HPLC indicated complete conversion. The organic layers were washed with hydrochloric acid (1 M), brine and dried over sodium sulfate. The solvent was removed under reduced pressure and the title compound was used directly without further purification.
The synthetic route of 34403-48-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BASF SE; TERTERYAN-SEISER, Violeta; GRAMMENOS, Wassilios; QUINTERO PALOMAR, Maria Angelica; CRAIG, Ian Robert; WIEBE, Christine; MENTZEL, Tobias; FEHR, Marcus; ESCRIBANO CUESTA, Ana; WINTER, Christian Harald; LOHMANN, Jan Klaas; MUELLER, Bernd; CAMBEIS, Erica; GROTE, Thomas; SEET, Michael; (36 pag.)US2020/45974; (2020); A1;,
Nitrile – Wikipedia,
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