Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2042-37-7, name is 2-Bromobenzonitrile, A new synthetic method of this compound is introduced below., Computed Properties of C7H4BrN
General procedure: activityThe catalytic activities of the prepared catalysts were testedfor the Suzuki-Miyuara cross-coupling reaction of phenylboronicacid with various bromoarenes. In a typical experiment, 0.70 mmolof the aryl bromide, 1.5 molar equivalents of phenylboronic acidand 1.5 molar equivalents of base, respectively, and 1.3 mmol ofanisole (internal standard) were dissolved in 20 ml of solvent. 5 mgof the catalyst (corresponding to approximately 0.05 mol% palla-dium) were added. The reaction was carried out under stirring at 75C. To monitor the reaction progress, samples from the reac-tion solution (100 l) were taken after 15, 30, 60, 90 and 120 min.HPLC sample solutions were prepared by dissolving 100 l of thereaction solution in 1 ml of the initial mobile phase. HPLC analy-sis was done using an Agilent 1100 series HPLC system (Agilent,Waldbronn, Germany), equipped with an online degasser, qua-ternary pump, autosampler, thermostatted column compartmentand UV-vis diode array detector. An Agilent Poroshell 120 EC-C18 reversed-phase column (50 × 4.6 mm; 2.7 m) was used asstationary phase. Analysis was carried out under gradient elu-tion conditions using a mobile phase consisting of methanol andaqueous phosphoric acid (water: phosphoric acid = 300:1 v/v). Col-umn temperature was set to 25C. UV-detection was performed atwavelengths of 237 and 270 nm over a run time of 15 min.
The synthetic route of 2042-37-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Lichtenegger; Maier; Hackl; Khinast; Goessler; Griesser; Kumar, V.S. Phani; Gruber-Woelfler; Deshpande; Journal of Molecular Catalysis A: Chemical; vol. 426; (2017); p. 39 – 51;,
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