Electric Literature of 1897-52-5, These common heterocyclic compound, 1897-52-5, name is 2,6-Difluorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 3 : 2-Fluoro-6- [1 -(2-fluorophenyl)piperidin-4- ylmethoxy]benzonitrile-(Method C).To a cold (ice water) suspension of sodium hydride (0.044 g, 1.1 mmol) in anhydrous DMF (1 mL) is added a solution of l-(2-fluorophenyl)piperidin-4-yl]methanol (0.19 g, 0.91 mmol) in anhydrous DMF (2 mL) over 11 minutes. After allowing to room temperature over 2 hours, this solution is added to a cold (ice water) stirred solution of 2,6-difluorobenzonitrile (0.14 g, 1.0 mmol) in anhydrous DMF (1 mL), and allowed to room temperature over 18 hours. The reaction mixture is poured into ice water with vigorous stirring and the resulting solid is filtered, washed with water, and dried under vacuum 1.5 hours to give 2-luoro-6-[l-(2-fluorophenyl)piperidin-4-yloxy]benzonitrile (0.19O g, 63% yield).
The synthetic route of 1897-52-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; deCODE Chemistry, Inc.; WO2008/16973; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts