Electric Literature of 64248-62-0, These common heterocyclic compound, 64248-62-0, name is 3,4-Difluorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Intermediate 34-(4-Ethyl-5-fluoro-2-methoxyphenoxy)-3-fluorobenzonitrile (D3)Molecular Weight =289,28Molecular Formula =C16H13F2N02To a solution of 4-ethyl-5-fluoroguaiacol (8 g; 47 mmol) and 3,4- difluorobenzonitrile (6.53 g ; 47 mmol; which may be prepared as hereinbefore described for D2) in 80 ml_ anhydrous acetonitrile is added FAB-P978PC – 11 Nov 0916potassium hydroxide (3.15 g ; 56.4 mmol). The reaction mixture under argon atmosphere is stirred under reflux for 16h. Concentration, addition of a saturated aqueous solution of ammonium chloride (100 mL), extraction with ethyl acetate (2*25 mL), reunification of the organic phases, brine wash (100 mL, drying (Na2S04) and final concentration affords 12.95 g (95%) of the title compound as a brown solid .MS (ES) m/e 290 (M + H)+ TLC : eluent cyclohexane/EtOAc 7/3 Rf = 0,74
The synthetic route of 64248-62-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; FAB PHARMA SAS; GERUSZ, Vincent; FAIVRE, Fabien; OXOBY, Mayalen; DENIS, Alexis; BONVIN, Yannick; WO2011/26529; (2011); A1;,
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