Electric Literature of 154607-01-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 154607-01-9, name is 4-Bromo-2-chlorobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
4-Bromo-2-chloro-cyanobenzne (2.Og, 9.3 mmol) and sodium perborate (4.3g, 28 mmol) were dissolved in dioxane (40ml), water (40ml) and heated at reflux for 1 hour. An extra 2.0 g of perborate was added and the reaction was refluxed for 1 hour. The reaction was cooled, extracted with DCM (2 x 100 ml), dried and the solvent was removed in vacuo to yield a white solid. Ether was added to dissolve any remaining starting material and the solid was stirred for 10 minutes and filtered (1.35g, 62%). NMR (299.954 MHz, CDCl3) 12.61 (s, IH), 12.50 (s, IH), 12.38 – 12.31 (m, 2H), 12.13 (d, IH).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-2-chlorobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/64251; (2006); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts