Synthetic Route of 21803-75-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 21803-75-8, name is 4-Amino-3-chlorobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of intermediate 79 (50 mg, 0.176 MMOL) in anh. DME (1 mL) were added Pd2 (dba) 3 (16 mg, 0.1 eq), 2- (dicyclohexylphosphino)-2′-methylbiphenyl (19 mg, 0.3 eq), K3PO4 (101 mg, 2.7 eq) and 4-amino-3-chlorobenzonitrile (47 mg, 1 eq). The reaction mixture was subjected to microwave irradiation (150W, 100 C, 60 psi) for 20 min. It was then quenched with sat. aq. NH4CI and extracted with EtOAc (2X10 mL). The combined organic extracts were washed with sat. aq. NaCI and dried over anh. NA2SO4. The solids were filtered and the solvent evaporated. The crude product was purified by flash chromatography (silica gel, cHex/EtOAc 8: 2- 7: 3) to give the title compound as a white solid (16 mg, 22%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Amino-3-chlorobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SB PHARMCO PUERTO RICO INC; NEUROCRINE BIOSCIENCES INC; GLAXO GROUP LIMITED; WO2004/62665; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts