Related Products of 5922-60-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5922-60-1, name is 2-Amino-5-chlorobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
2-amino-5-chlorobenzonitrile (1.00 g, 6.55 mmol) was suspended in ethyl chloroformate (3.1 mL, 33 mmol) and heated to 93 °C. The reaction was carried out for 18 h, cooled to room temperature and then worked up with a saturated solution of sodium bicarbonate and EtOAc. No further purification was required. The reaction yielded an orange solid 1.25 g, 5.56 mmol, 85percent. (Rf = 0.30, 20percent EtOAc/Hex). Mp 136-138 °C. 1H NMR (300 MHz, CDCl3) delta 8.29 – 8.22 (m, 1H, ArH), 7.59 – 7.52 (m, 2H, ArH), 7.13 (s, 1H, NH), 4.29 (q, J = 7.1 Hz, 2H, CH2), 1.36 (t, J = 7.1 Hz, 3H, CH3). 13C NMR (75 MHz, CDCl3) delta 152.68, 139.68, 134.47, 131.44, 128.14, 120.59, 117.64, 115.11, 62.27, 14.37. HRMS: calcd for C10H10N2O2Cl [M+H]+, 225.0431, found 225.0426.
The synthetic route of 2-Amino-5-chlorobenzonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Article; Brigg, Siobhan; Pribut, Nicole; Basson, Adriaan E.; Avgenikos, Moscos; Venter, Reinhardt; Blackie, Margaret A.; van Otterlo, Willem A.L.; Pelly, Stephen C.; Bioorganic and Medicinal Chemistry Letters; vol. 26; 6; (2016); p. 1580 – 1584;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts