Some common heterocyclic compound, 17823-40-4, name is 4-Bromo-2,3,5,6-tetrafluorobenzonitrile, molecular formula is C7BrF4N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 17823-40-4
1.14 cm3 of hydrazine monohydrate are added to 2.0 g of 4-bromo-2,3,5,6-tetrafluorobenzonitrile in 40 cm3 of absolute ethanol. The mixture is refluxed for 18 hours, 30 cm3 of distilled water are then added and the reaction medium is concentrated under reduced pressure (2 kPa; 50 C.). The residue is taken up in 100 cm3 of ethyl acetate and 10 cm3 of water, and the organic phase is separated out after settling of the phases has taken place, dried over magnesium sulphate, filtered and concentrated to dryness under reduced pressure (2 kPa; 50 C.); after drying (90 Pa; 40 C.), 2.1 g of 6-bromo-4,5,7-trifluoro-1H-indazole-3-amine are obtained in the form of a beige-coloured solid. [0959] 1H NMR spectrum (300 MHz, (CD3)2SO-d6, delta in ppm): 5.52 (s: 2H); from 12.10 to 12.90 (broad unresolved peak: 1H). [TABLE-US-00076] EI m/z = 265M+. m/z = 236[M – HN2]+ m/z = 186[M – Br]+
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 17823-40-4, its application will become more common.
Reference:
Patent; Dutruc-Rosset, Gilles; Lesuisse, Dominique; Rooney, Thomas; Halley, Franck; US2004/14802; (2004); A1;,
Nitrile – Wikipedia,
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