13338-63-1, name is 3,4,5-Trimethoxyphenylacetonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 3,4,5-Trimethoxyphenylacetonitrile
General procedure: To a mixture of DBU (20 mol%) in DMSO (4 mL) were added 2 (1.5 equiv) and benzyl cyanide (50 mg, 1 equiv). The reaction mixture was stirred at r.t. for 3 h. Then, aq NH4Cl was added dropwise. H2O and EtOAc were added and the phases were separated. The aqueous layer was extracted with EtOAc. The organic phase was dried (MgSO4) and filtered. The solvent was evaporated under reduced pressure to give an oil, which was purified by column chromatography. The solvent polarity was increased via a gradient from neat petroleum ether (PE) to a mixture of EtOAc/PE (Table 1).
The synthetic route of 13338-63-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Campos, Joana F.; Queiroz, Maria-Joao R. P.; Berteina-Raboin, Sabine; Synthesis; vol. 50; 5; (2018); p. 1159 – 1165;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts