Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 17417-09-3, name is 2-Fluoro-5-nitrobenzonitrile, A new synthetic method of this compound is introduced below., category: nitriles-buliding-blocks
2-Fluoro-5-nitrobenzonitrile (50 g, 0.3 mol) was dissolved in 500 ml of dimethylsulfoxide and potassium carbonate (49.7 g,0.36 mol) and sodium methanesulfinate (36.7 g, 0.36 mol) was added.Heated to 100 C overnight reaction, TLC detection (EpsilonAlpha: PE =1: 1), the reaction is over.After the reaction solution was poured into 100 mL of water, no solid was precipitated, and extracted with EA (250 mL * 4). The combined EA phases and sulfuric acidSodium dried, concentrated by column chromatography to give a yellow brown solid (5g, yield 7.4%);Intermediate 5g suspended in 100mL of water, add10 mL of concentrated hydrochloric acid was added and the mixture was stirred for 30 minutes. TLC (EA: PE = 1: 1) was performed. The reaction was completed and the reaction mixture was extracted with DCMTake, merge DCM phase three times,Saturated brine (100mL * l), the organic phase was dried over sodium sulfate, concentrated to give a solid which was purified by column chromatography to give a yellow powder (3.00g, 7.3 ·)
The synthetic route of 17417-09-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Qidong Shaoyuan Chemical Technology Co., Ltd.; Li Shaobo; Wu Yong; Gai Hongguang; Xie Chunhui; Guo Meng; (5 pag.)CN104744429; (2016); B;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts