In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2973-50-4, name is 2-(2-Aminophenyl)acetonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C8H8N2
To (2-aminophenyl)acetonitrile (10 g, 75.7 mmol) in DMF (100 ml) was added benzyl bromide (12.9 g, 75.7 mmol) and potassium carbonate (16.6 g, 1 13.5 mmol) at RT. The reaction was stirred at RT overnight. Reaction was filtered and the solvent was removed. The resulting mixture was extracted with EtOAc and washed with water and sat. sodium chloride (aq). The organic layer was dried, then solvent was removed. The mixture was chromatographed on silica gel (Hexand:EtOAc) and gave the titled compound (9.94g, 59%).
The synthetic route of 2973-50-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER AKTIENGESELLSCHAFT; GRAHAM, Keith; BUCHGRABER, Philipp; AIGUABELLA FONT, Nuria; HEINRICH, Tobias; BRAeUER, Nico; KUHNKE, Lara, Patricia; WITTROCK, Sven; LANGE, Martin; BADER, Benjamin; PRECHTL, Stefan; LIENAU, Philip; KOPITZ, Charlotte, Christine; NOWAK-REPPEL, Katrin; POTZE, Lisette; STEUBER, Holger; HARVEY, Rebecca, Ann; KIRK, Ralph, Steven; (699 pag.)WO2020/48829; (2020); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts