Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 14447-18-8, name is Benzyl cyanoacetate, A new synthetic method of this compound is introduced below., Quality Control of Benzyl cyanoacetate
A stirred mixture of naltrexone (1.70 g; 5.0 mmol), benzyl cyanoacetate (1.31 g; 7.5 mmol) and sulfur (0.24 g; 7.5 mmol) in DMF (15 mL) was treated dropwise at room temperature with morpholine (0.66 mL; 7.6 mmol) and the mixture was then heated under reflux at 80 C. for 24 h. The reaction mixture was allowed to cool to room temperature and poured over ice-water mixture. The solid obtained was collected by filtration, washed with water and dried. The crude product was purified by flash chromatography over a column of silica using CHCl3-MeOH (99:1) as the eluent to obtain 8d (1.16 g): mp 208-212 C. dec; TLC, Rf 0.69 (CHCl3-MeOH 9:1).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Southern Research Institute; US2006/47119; (2006); A1;,
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