The synthetic route of 149793-69-1 has been constantly updated, and we look forward to future research findings.
149793-69-1, name is 3-Fluoro-5-(trifluoromethyl)benzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 3-Fluoro-5-(trifluoromethyl)benzonitrile
Reference Compound 1C and ID sodium 3-(4-(pyrrolidin-l-yl)piperidin-l-yl)-5-(trifluoromethyl)benzoate and 3-(4- (pyrrolidin-l-yl)piperidin-l-yl)-5-(trifluoromethyl)anilineScheme 1: Synthesis of Reference Compound 1 (compounds 1-C and 1-D) 1-A 1-B 1 -C [0079] Reagents and conditions: (a) 4-(pyrrolidine-l-yl) piperidine, K2CO3, DMSO,800C; (b) i. 50% H2SO4, reflux; ii. NaOH, 2 steps; (c) DPPA, Et3N, DCM, rt; (d). TFA,DCM, rt.[0080] 1-B: To a stirred solution of 1-A (6.49 g, 34.2 mmol) in 50 mL of DMSO is added 4-(pyrrolidine-l-yl) piperidine (5.80 g, 37.6 mmol) and K2CO3 (5.20 g, 37.6 mmol) at room temperature. The reaction mixture is stirred at 80 0C for 1 hour. HPLC/MS test indicates the complete consumption of I- A) and a single new peak with the right mass for 1-B ([M+l] = 324).[0081] The reaction mixture is diluted with ethyl acetate and washed with water and brine. The organic solution is dried over Na2SO4 and concentrated. The crude product is used directly in the next step without further purification.
The synthetic route of 149793-69-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; IRM LLC; DANA FARBER CANCER INSTITUTE; WO2009/152356; (2009); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts