Synthetic Route of 654-70-6, These common heterocyclic compound, 654-70-6, name is 4-Cyano-3-trifluoromethylaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
At 0C,Compound 16a (25.00 g, 134.31 mmol)Liquid bromine (21.68 g, 135.66 mmol) was slowly added dropwise to a solution of methanol (200 mL).The resulting reaction solution was continuously stirred for 0.5 hours.At 0C,Saturated sodium thiosulfate solution (200 mL) was added to the reaction system to quench the reaction, then diluted with water (1000 mL), filtered, and the solid was washed with water (200 mL×3).After drying under reduced pressure, compound 16b (34.30 g) was obtained.
The synthetic route of 654-70-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Zhengda Tianqing Pharmaceutical Group Co., Ltd.; Nanjing Mingde Drug Discovery Co., Ltd.; Yao Yuanshan; Chen Bin; Chen Yuan; Li Ao; Xu Ran; Huang Zhensheng; Tian Dongdong; Li Hongwei; Yang Chengshuai; Li Jian; Chen Shuhui; (30 pag.)CN107954995; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts