Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 654-70-6, name is 4-Cyano-3-trifluoromethylaniline, A new synthetic method of this compound is introduced below., Recommanded Product: 654-70-6
Synthesis of (2R)-3-Bromo-N-[4-cyano-3-(trifluoromethyl) phenyl]-2-hydroxy-2- methylpropanamide. Thionyl chloride (46.02 g, 0.39 mol) was added dropwise to a cooled solution (less than 4 C) of 6 (51.13 g, 0.28 mol) in 300 mL of THF under an argon atmosphere. The resulting mixture was stirred for 3 h under the same condition. To this was added Et3N (39.14 g, 0.39 mol) and stirred for 20 min under the same condition. After 20 min, 5-amino-2- cyanobenzotrifluoride (40.0 g, 0.21 mol), 400 mL of THF were added and then the mixture was allowed to stir overnight at room temperature. The solvent was removed under reduced pressure to give a solid which was treated with 300 mL of H2O, extracted with EtOAc (2 X 400 mL). The combined organic extracts were washed with saturated NaHCO3 solution (2 X 300 mL) and brine (300 mL). The organic layer was dried over MgSO4 and concentrated under reduced pressure to give a solid which was purified from column chromatography using CH2Cl2ZEtOAc (80:20) to give a solid. This solid was recrystallized from CH2Cl2/hexane to give 55.8 g (73.9%) of (2R)-3- Bromo-N-[4-cyano-3-(trifluoromethyl) phenyl] -2-hydroxy-2-methylpropanamide as a light- yellow solid. 1H NMR (CDC13/TMS) delta 1.66 (s, 3H, CH3), 3.11 (s, 1eta, OH), 3.63 (d, / = 10.8 Hz, IH, CH2), 4.05 (d, / = 10.8 Hz, IH, CH2J, 7.85 (d, / = 8.4 Hz, IH, ArH), 7.99 (dd, / = 2.1, 8.4 Hz, IH, ArH), 8.12 (d, / = 2.1 Hz, IH, ArH), 9.04 (bs, 1eta, NH). Calculated Mass: 349.99, [M-H]- 349.0. M.p.: 124-126 0C.
The synthetic route of 654-70-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION; AHN, Tai; WO2009/36206; (2009); A1;,
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