Related Products of 7357-70-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7357-70-2 as follows.
ferf-butyl 4-(4-(3-amino-2-cyano-3-thioxoprop-1 -enyl)-3- nitrophenyl)piperazine-1 -carboxylate1.5 g (15 mmol) of 2-cyanoethanethioamide, 60 ml of ethanol and one drop of piperidine are added respectively to 5 g (15 mmol) of tert-butyl 4-(4-formyl-3- nitrophenyl)piperazine-l -carboxylate. The reaction mixture i s sti rred at room temperature for 12 hours. The precipitate obtained is filtered to yield 5.2 g (83%) of tert-b u t y 1 4-(4-(3-amino-2-cyano-3-thioxoprop-l-enyl)-3-nitrophenyl)piperazine-l- carboxylate in the form of a yellow solid.LCMS (ESI, m/z): (M+l) 418.481H MR: 6H pm 400 MHz, DMSO: 10.10 (IH, bs, NH), 9.45 (IH, bs, NH), 8.25 (IH, CHarom), 7.95 (IH, d, CHarom), 7.60 (IH, d, CHarom), 6.35 (IH, dd, CHarom), 3.50 (8H, i 4CH2), 1.42 (9H, s, 3CH3).
According to the analysis of related databases, 7357-70-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PIERRE FABRE MEDICAMENT; RABOT, Remi; BEDJEGUELAL, Karim; KALOUN, El Bachir; SCHMITT, Philippe; RAHIER, Nicolas; MAYER, Patrice; FOURNIER, Emmanuel; WO2012/140114; (2012); A1;,
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