Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3598-13-8, name is 2-(4-Chlorophenoxy)acetonitrile, A new synthetic method of this compound is introduced below., name: 2-(4-Chlorophenoxy)acetonitrile
Intermediate 2; 7-methoxy-3-piperidin-4-yl-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one; Step 1: (5-methoxy-2-nitrophenyl)-acetonitrile; 24.0 g (214 mmol) potassium-tert-butoxide in 100 mL DMF were slowly added dropwise to a solution of 13.2 g (86.0 mmol) 4-nitroanisole and 18.0 g (107 mmol) of 4-chlorophenoxy-acetonitrile in 50 mL DMF. The reaction mixture was stirred for 30 min at -10 C. and then poured into 300 g of a 1:1 mixture of conc. HCl and ice. After extraction with EtOAc the organic phase was washed with water, dried and evaporated down i. vac. The residue was treated with a 1:1 mixture PE/EtOAc and the product that crystallised out was suction filtered. After washing with a 1:1 mixture of petroleum ether/EtOAc the crystals were dried in the air.Yield: 6.5 g (39% of theoretical)ESI-MS: m/z=210 (M+NH4)+ Rf: 0.45 (silica gel; PE/EtOAc=1:1)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2010/324028; (2010); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts