Synthetic Route of 57381-34-7, These common heterocyclic compound, 57381-34-7, name is 5-Chloro-2-fluorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 53 5-Chloro-2-(2-methyl-4-pyrrolidin-1-yl-quinolin-7-ylmethoxy)-benzonitrile The title compound was produced in accordance with the general method of example 6 from (2-methyl-4-pyrrolidin-1-yl-quinolin-7-yl)-methanol (example 2) and 5-chloro-2-fluorobenzonitrile. Light yellow solid, ISP-MS: m/e=378.4 ([M+H]+).
The synthetic route of 57381-34-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Klug, Michael G.; Mattei, Patrizio; Mueller, Werner; Neidhart, Werner; Nettekoven, Matthias Heinrich; Pflieger, Philippe; Plancher, Jean-Marc; US2003/158179; (2003); A1;,
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