Electric Literature of 159847-81-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 159847-81-1 name is Methyl 2-amino-5-cyanobenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Methyl [2-AMINO-5-CYANOBENZOATE] (5.0 g, 28.41 mmol) was dissolved in MeOH (105 mL). Then 6M [NAOH] (14 mL) was added. The resulting mixture was stirred at RT O/N. The reaction mixture was diluted with H20 (143 mL), washed with DCM to remove any unreacted S. M. The product was precipitated from aqueous layer by addition of conc. [HC1] to pH 1 and extracted with EtOAc (3 x 100 mL). The combined organic layers were dried over MgS04 Solid was removed by filtration, and filtrate was concentrated to dryness under reduced pressure. The light yellow product was obtained in the yield of 94%. [‘H NMR] (300 MHz, DMSO-d6) 8 8.08 (d, 1H), 7.56 (dd, [1H),] 7.50 (br), 6.85 (d, 1H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 2-amino-5-cyanobenzoate, and friends who are interested can also refer to it.
Reference:
Patent; PHARMACIA & UPJOHN COMPANY; WO2004/18428; (2004); A1;,
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Nitriles – Chemistry LibreTexts