These common heterocyclic compound, 34667-88-4, name is 2-Fluoro-4-nitrobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 34667-88-4
To 2-fluoro-4-nitrobenzonitrile (8.5 g, 51.2 mmol) was added 10% palladium on carbon (0.5 g) and EtOAc (42.5 mL) and EtOH (170 mL) and the reaction was hydrogenated at 50 psi for 1 h. The reaction was filtered through Celite and the reaction mixture was concentrated to afford 6.7 g (96% yield) as a light brown solid. LCMS m/z 135.1[M + H]+.
The synthetic route of 2-Fluoro-4-nitrobenzonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2008/157162; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts