Related Products of 243128-37-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 243128-37-2 as follows.
4-fluoro-3-methoxybenzonitrile (1 g, 6.62 mmols) was dissolved in anhydrous dichloromethane (10 mL) and cooled to 0 C. (ice-bath). To the cooled solution was added boron tribromide solution in dichloromethane (1 M, 2 eq.). The reaction mixture was stirred at 0 C. for 5 minutes, warmed to room temperature and stirred at room temperature overnight. LCMS of the reaction mixture showed some starting material was still present. Two more equivalents of boron tribromide solution was added and the reaction was stirred at RT overnight. LCMS showed that the reaction had progressed, but some starting material was still present. The reaction mixture was then heated at 45 C. overnight to complete the reaction, as confirmed by LCMS. The reaction mixture was then poured into ice-water, warmed to RT, and extracted with ethyl acetate (3*). The combined organic layer was dried over sodium sulfate, filtered and concentrated to give the crude phenol which was used in the next step without further purification.
According to the analysis of related databases, 243128-37-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Ge, Min; He, Jiafang; Lau, Fiona Wai Yu; Liang, Gui-Bai; Lin, Songnian; Liu, Weiguo; Walsh, Shawn P.; Yang, Lihu; US2007/265332; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts