In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 124289-21-0, name is 3-Bromo-5-methylbenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 3-Bromo-5-methylbenzonitrile
a) Preparation of Compound 43B (0368) To a solution of 3-bromo-5-methylbenzonitrile (1.0 g, 5.12 mmol) in MeOH (40 mL) was added NiCl2.6H2O (121 mg, 0.51 mmol), Boc2O (1.35 g, 6.20 mmol) and NaBH4 (780 mg, 20.5 mmol) at -20 C. Then the mixture was stirred for 2 hrs at 0-10 C. The reaction solution was quenched with sat. NH4Cl (120 mL), diluted with H2O (200 mL) and extracted with EA (100 mL×3). The combined organic layers were washed by brine (50 mL×2), dried over Na2SO4 and concentrated to give tert-butyl 3-bromo-5-methylbenzylcarbamate (Compound 43B, 1.3 g, 86.7%) as a white solid. MS: calc’d 300 (M+H)+, measured 300 (M+H)+.
The synthetic route of 124289-21-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Hoffmann-La Roche Inc.; Hoves, Sabine; Wang, Lisha; Yun, Hongying; Zhang, Weixing; Zhu, Wei; (58 pag.)US2016/257653; (2016); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts