In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1835-65-0, name is 3,4,5,6-Tetrafluorophthalonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 1835-65-0
Referential Example 1 Synthesis of 4,5-bis(2,5-dichlorophenoxy)-3,6-difluorophthalonitrile Into a separable flask of glass provided with a stirrer, a thermometer, a water separation tube, and a cooling tube and having an inner volume of 300 ml, 242.5 gr of acetone and 19.1 gr (0.0955 mol) of tetrafluorophthalonitrile were placed, to dissolve tetrafluorophthalonitrile in acetone homogeneously. Next, the resultant solution and 134 gr (0.2306 mol) of potassium fluoride were added together and the resultant reaction slurry was retained at -5° C. To this reaction slurry, 34.1 gr (0.2092 mol) of 2,5-dichlorophenol dissolved uniformly in 30.5 gr of acetone was added dropwise over a period of one hour. The reaction proceeding during the dropwise addition was continued with the reaction product cooled from the exterior so as to keep the interior temperature thereof in the range of -5° C. to 0° C. After the dropwise addition was completed, the reaction mixture was retained for additional two hours. After the reaction was completed, the contents of the flask were cooled to 20° C. and filtered to separate the solid component. The solid component was washed with 10 gr of acetone and the washed solid component and the filtrate were mixed together. The resultant filtrate was evaporated under a reduced pressure to expel acetone by distillation. The weight of the produced dry component was 45.8 gr (crude yield: 98.7 mol). This dry component was found to contain 42.9 gr of the target product, 4,5-bis(2,5-dichlorophenoxy)-3,6-difluorophthalonitrile (yield: 92.4 mol percent).
The synthetic route of 1835-65-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Hirota, Kouichi; Hashimoto, Yukihide; Masuda, Kiyoshi; Kitao, Masunori; US2005/203293; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts