Adding a certain compound to certain chemical reactions, such as: 2032-34-0, name is 3,3-Diethoxypropanenitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2032-34-0, Safety of 3,3-Diethoxypropanenitrile
To a stirred solution of 3,3-diethoxypropane-nitrile (1-iA, 283.80 g, 1.98 moles) and methyl formate (I- IB, 148.80 g, 2.48 moles) in anhydrous THF (1.1 L) at 10 C was added 1.0 M potassium tert-butoxide in THF (2.2 L. 2.2 moles). The temperature was maintained in the range of 10 C to 15 C throughout the 45 minute addition. Following the addition, the resulting slurry was stirred for 2 hours at ambient temperature. Hexane (400 niL) was then added and stirring was continued for another 20 min. The slurry was filtered and the cake washed with 1/1 hexanes/THF and dried overnight at 60 CC in a vacuum oven to provide I-1C.?H-NMR (CD3OD) was consistent with the desired structure.
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Reference:
Patent; GILEAD SCIENCES, INC.; AMMANN, Stephen; BACON, Elizabeth M.; BRIZGYS, Gediminas; CHIN, Elbert; CHOU, Chienhung; COTTELL, Jeromy J.; NDUKWE, Marilyn; TAYLOR, James G.; WRIGHT, Nathan E.; YANG, Zheng-Yu; ZIPFEL, Sheila M.; (138 pag.)WO2020/36979; (2020); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts