Application of 630-18-2,Some common heterocyclic compound, 630-18-2, name is Pivalonitrile, molecular formula is C5H9N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
5) Example 1-5:Preparation of methyl trimethylacetimidate hydrochlorideTo a reactor were added 1.6 kg of trimethylacetonitrile and 1.48 kg of methanol andthe reactor was cooled to -10C. Acety 1 chloride in the amount of 1. 81 kg was slow 1 yadded thereto and the mixture was stirred at 0Cfor 12 hours. While stirring, theinternal temperature of the reactor was maintained at ooc. Upon termination of thereaction, the solvent was removed at 45C under reduced pressure. To the reactionmixture was added 11.8 kg of tert-butyl methyl ether and the mixture was stirred at oocfor 3 hours. The resulting solid was filtered and vacuum-dried at 40C to obtain 2.63kg of methyl trimethylacetimidate hydrochloride (yield: 90% ).1H-NMR (400MHz, DMSO-d6): 11.7(s, 2H), 4.07(s, 3H), l.O(s, 9H)
The synthetic route of 630-18-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CJ HEALTHCARE CORPORATION; KWEON, Jae Hong; KIM, Eun Sun; SONG, Seog Beom; LEE, Sung Ah; LEE, Ji Yun; CHOI, Kwang Do; PARK, Young Joon; WO2015/5615; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts