Synthetic Route of 78881-21-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 78881-21-7 name is 4-Amino-3-methylbenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
step 1-To a solution of 26a (1 mmol) in IPA was added 4-methyl-4-amino-benzonitrile (104, 1 mmol) then concentrated HCl (5 drops). The solution was stirred at 100 C. overnight. The reaction mixture was cooled and the resulting precipitate was filtered and washed thoroughly with IPA to afford 0.204 g (80%) of 106a.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Amino-3-methylbenzonitrile, and friends who are interested can also refer to it.
Reference:
Patent; Roche Palo Alto LLC; US2008/146595; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts