Application of 26391-06-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 26391-06-0, name is 2-Cyano-N,N-diethylacetamide belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: A solution of arylaldehyde (1 equiv), 2-cyanoacetamide or derivative (1.0-1.5 equiv) and N-methylpiperazine (0.05-1.05 equiv) in methanol (2-10 ml) was stirred at room temperature overnight. After addition of an equivalent volume of water/methanol (1:1) or 1 N HCl/methanol (1:1) for acidic products, the precipitate was collected by filtration and washed with water/methanol (1:1). If precipitation did not occur, the mixture was evaporated and the residue was purified by flash chromatography.
The synthetic route of 2-Cyano-N,N-diethylacetamide has been constantly updated, and we look forward to future research findings.
Reference:
Article; Nitsche, Christoph; Steuer, Christian; Klein, Christian D.; Bioorganic and Medicinal Chemistry; vol. 19; 24; (2011); p. 7318 – 7337;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts