In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 499983-13-0, name is 4-Bromo-3-fluorophenylacetonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 499983-13-0
EXAMPLE 3Preparation of ethyl 3-fluoro-4-bromo-phenylacetate from 3-fluoro-4-bromo-phenylacetonitrile2.5 g of 3-fluoro-4-bromo-phenylacetonitrile, 4.7 g. of ethyl alcohol and 4.7 g of sulfuric acid were loaded at room temperature in an reactor. The mixture was heated to 100 C and stirred for 5 hours. When the conversion was completed, the mixture was cooled to room temperature, water and ethyl acetate were added and the aqueous phase was re-extracted with fresh ethyl acetate. The organic phase was washed with a sodium bicarbonate/water solution, then with water until pH=7. The organic phase was concentrated to yield 2.6 g, of crude product.
The synthetic route of 499983-13-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CHIESI FARMACEUTICI S.p.A; VERZINI, Massimo; Cotarca, Livius; Guidi, Alberto; Melloni, Alfonso; Maragni, Paolo; US2014/378696; (2014); A1;,
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