Synthetic Route of 2973-50-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2973-50-4, name is 2-(2-Aminophenyl)acetonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a stirred solution of 6-(difluoromethyl) pyridazine-4-carboxylic acid Int-29 (1 g, 5.75 mmol) in ethylacetate (60 mE) was added 2-(2-aminophenyl)acetoni- trile (759 mg, 5.75 mmol) andtriethylamine (1.6 mE, 11.49 mmol) at room temperature under an inert atmosphere. To this was added propylphosphonic anhydride (50% in EtOAc, 9.14 mE, 14.37 mmol) drop wise at 00 C. The reaction mixture was gradually warmed to room temperature and stirred for 2 h. After consumption of starting material (by TEC), the reaction mixture was basified using saturated sodium bicarbonate solution to pH .-8 and extracted with EtOAc (2×50 mE). The combined organic extracts were dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude material was triturated with n-pentane (2×25 mE) and dried under vacuum to afford N-(2-(cyanomethyl)phenyl)-6-(difluoromethyl)pyridazine- 4-carboxamide (1.4 g, 4.86 mmol, 85%) as a yellow solid.11619] ?H NMR (500 MHz, DMSO-d5): oe 10.77 (s, 1H),9.80 (s, 1H), 8.45 (s, 1H), 7.54-7.49 (m, 1H), 7.45-7.30 (m, 4H), 4.02 (s, 2H)11620] EC-MS: mlz 288.9 [M+H] at 2.25 RT (98.33% purity)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2-Aminophenyl)acetonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Viamet Pharmaceuticals (NC), Inc.; Sparks, Steven; Yates, Christopher M.; Shaver, Sammy R.; Hoekstra, William J.; (156 pag.)US2018/185362; (2018); A1;,
Nitrile – Wikipedia,
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