Reference of 403-54-3, These common heterocyclic compound, 403-54-3, name is 3-Fluorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of nitrile (10 mmol), halohydrocarbons (11 mmol) and FeCl2·4H2O (2 mol %) was placed in a round bottom flask. Then the reaction mixture was heated at 80 C for the given time. After completion of the reaction monitored by thin layer chromatography (TLC), 5 ml water was added into reaction system and extracted with ethyl acetate (3 × 5 ml). The organic layers were collected, combined, washed with water (3 × 10 ml), dried over anhydrous Na2SO4, and concentrated under vacuum. The pure product was obtained by directly passing through a silica gel (200-300 mesh) column using petroleum ether/ethyl acetate and identified by 1HNMR and 13C NMR.
Statistics shows that 3-Fluorobenzonitrile is playing an increasingly important role. we look forward to future research findings about 403-54-3.
Reference:
Article; Feng, Cheng-Liang; Yin, Gui-Bo; Yan, Bin; Chen, Jun-Qing; Ji, Min; Chemical Papers; vol. 73; 2; (2019); p. 345 – 353;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts