Reference of 1558-81-2, These common heterocyclic compound, 1558-81-2, name is Ethyl 1-Cyano-1-cyclopropanecarboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 97A (Enantiomer 1)Step V ” l-(hydroxymethyl)cycJopropanecarbonitriotale; HO “^ANi NAt r.t to a solution of ethyl 1-cyanocyclopropanecarboxylate (1.0 g, 7.2 mmol; Aldrich, Cat. No. 543055) in tetrahydrofuran (15 mL) was added lithium tetrahydroborate (0.31 g, 14 mmol) portionwise with stirring. The resuting mixture was heated at reflux for 3 h. After cooling, it was quenched with water. The product was extracted with ethyl acetate. The extract was washed with water and brine, dried over Na2SO4. After filtration the filtrate was concentrated to yield 0.41 g of the product which was used directly in next step reaction without further purification.
The synthetic route of 1558-81-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; INCYTE CORPORATION; ZHANG, Colin; QIAN, Ding-quan; ZHUO, Jincong; YAO, Wenqing; WO2010/75270; (2010); A1;,
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