Electric Literature of 4513-77-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4513-77-3, name is 2-Oxocyclohexanecarbonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: A solution of 2-oxocyclohexanecarbonitrile (59, 2.57 g, 20.9 mmol) and ethyl hydrazineoxalate (60, 4.70 g, 31.3 mmol) in ethanol(40 mL) was stirred at reflux for 18 h, cooled to room temperature and thesolvent removed under reduced pressure.The residue was diluted with methylene chloride (150 mL) and saturatedaqueous sodium bicarbonate (100 mL) was added.The organic layer was separated and the aqueous layer was furtherextracted with methylene chloride (2 ×100 mL).The combined organic layers were washed with brine (50 mL), dried (MgSO4),filtered and concentrated under reduced pressure. The resulting residue was further purified byflash column chromatography on silica gel, eluting with methanol/methylenechloride (gradient of 2:98 to 4:96) to afford 2-ethyl-4,5,6,7-tetrahydro-2H-indazol-3-amine (61) as a while solid(2.73 g, 79%)
The synthetic route of 2-Oxocyclohexanecarbonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Article; Rynearson, Kevin D.; Buckle, Ronald N.; Barnes, Keith D.; Herr, R. Jason; Mayhew, Nicholas J.; Paquette, William D.; Sakwa, Samuel A.; Nguyen, Phuong D.; Johnson, Graham; Tanzi, Rudolph E.; Wagner, Steven L.; Bioorganic and Medicinal Chemistry Letters; vol. 26; 16; (2016); p. 3928 – 3937;,
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